Tmem173 sting

Author: qbek

August undefined, 2024

Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a protein that in humans is encoded by the STING1 gene. STING plays an important role in innate immunity. STING induces type I interferon production when cells are infected with intracellular pathogens, suc… Websting途径在介导胞质dna的识别中至关重要。在这种情况下，sting是一种定位于内质网(er)的跨膜蛋白，它充当由dsdna结合后cgas产生的2’,3’环状gmp-amp(以下简称cgamp)的第二信使受体。此外，sting还可以用作细菌环状二核苷酸(cdn)和小分子激动剂的主要模式识别受体。

Novel TMEM173 Mutation and the Role of Disease …

Web检测原理： Transmembrane protein 173(TMEM173)ELISA检测试剂盒采用双抗体夹心酶联免疫吸附检测方法。向预包被了抗体的微孔板中，加入标准品和待测样本，温育后，加入生物素标记抗体和过氧化物酶标记的链霉亲和素。 WebMar 17, 2024 · Introduction. Stimulator of interferon response cGAMP interactor 1 (STING1, also known as STING or TMEM173), an evolutionarily conserved transmembrane protein, is expressed in various endothelial and epithelial cell types as well as in T cells, B cells, and myeloid cells (e.g., macrophages and monocytes) and mainly localized on endoplasmic … barbara klein utica ny

内质网自噬及其与疾病的关系研究进展_参考网

WebDec 6, 2024 · The upregulation of STING ( Tmem173) transcripts seen in WT mice 7 days after silica exposure was further increased in cGAS −/− mice, while cGAS ( Mb21d1) transcript upregulation was not... WebTMEM173 / STING transmembrane protein 173. Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the ... WebBackground: STING/TMEM173. STING (Stimulator of Interferon Genes), also called ERIS, MPYS, or MITA and designated TMEM173, is a 40-42 kDa 4-transmembrane protein that mediates both antiviral and MHC-II antigen recognition responses. STING is found predominantly in the endoplasmic reticulum. It acts as an adaptor protein for intracellular … barbara klein youtube

Tmem173 sting

STING/TMEM173 Antibody [PE] (NBP2-24683PE): Novus Biologicals

WebTMEM173 transmembrane protein 173 Background STING (stimulator of interferon genes) is encoded by the TMEM173 gene and is an adaptor molecule involved in the activation of … WebJul 16, 2014 · We sequenced a candidate gene, TMEM173, encoding the stimulator of interferon genes (STING), in this patient and in five unrelated children with similar clinical …

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WebJan 3, 2024 · Interestingly, human TMEM173/STING exhibits significant heterogeneity [ 27, 28 ]. The second most common allele besides the WT allele is HAQ, which contains a haplotype comprised of the three non-synonymous single nucleotide polymorphisms (SNPs) R71 H -G230 A -R293 Q. WebStimulator of interferon genes (STING, also known as ERIS, MITA and MPYS, and encoded by TMEM173) is a transmembrane adaptor protein that facilitates innate immune signaling …

Web张慧芳，黄自能，陈蔚，孙林，刘伏友，肖力. 1中南大学湘雅二医院肾内科，长沙 410000. 自噬是消除聚集的蛋白质及受损细胞器的过程，对于缓解应激、维持细胞稳态及细胞分化等至关重要[1-2]。 WebIt has been reported that ER serves as a platform for activation of IRF3 by cytosolic RNA or DNA of viral origin and that during certain viral infections, IRF3 associates with ER via binding to Stimulator of IFN genes (STING, also known as TMEM173 or MPYS), an adaptor molecule residing in the ER membrane (11). To explore whether interaction ...

WebJan 28, 2024 · Total Structure Weight: 85.97 kDa Atom Count: 4,586 Modelled Residue Count: 584 Deposited Residue Count: 770 Unique protein chains: 1 Display Files Download Files 6NT5 Cryo-EM structure of full-length human STING in the apo state PDB DOI: 10.2210/pdb6NT5/pdb EM Map EMD-0502: EMDB EMDataResource Classification: … WebBackground: STING/TMEM173. STING (Stimulator of Interferon Genes), also called ERIS, MPYS, or MITA and designated TMEM173, is a 40-42 kDa 4-transmembrane protein that …

WebDec 11, 2024 · PMID: 31026807 DOI: 10.4049/immunohorizons.1800068 Abstract The innate immune system provides a primary line of defense against pathogens. Stimulator of IFN genes (STING), encoded by the TMEM173 gene, is a critical protein involved in IFN-β induction in response to infection by different pathogens.

WebJul 30, 2024 · Accumulating evidence now points to STING as a source of severe pathology in human disease. Most recently, gain-of-function mutations in the gene encoding STING (TMEM173) have been shown to drive a systemic and debilitating inflammatory condition known as stimulator of IFN genes-associated vasculopathy with onset in infancy (SAVI) . barbara klein shopWebThe TMEM173 gene, also known as STING1, encodes an adaptor protein that mediates the production of beta-interferon (IFNB1; 147640 ). STING is a transmembrane protein in the … barbara klemm obituaryWebStimulator of interferon genes (STING, also known as ERIS, MITA and MPYS, and encoded by TMEM173) is a transmembrane adaptor protein that facilitates innate immune … barbara klepperWebMar 29, 2024 · STING-associated vasculopathy with onset in infancy (SAVI) is an autoinflammatory disease caused by gain-of-function mutations in TMEM173. Data … barbara klemm ludwiggalerie oberhausenWebThis product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility. - Improved sensitivity and … barbara klepper obituaryWeb髓系细胞TMEM173 (STING)被证明在CLP、大肠杆菌或肺炎链球菌诱导的实验性脓毒症中通过GSDMD激活驱动组织因子释放和凝血。参与TMEM173介导GSDMD裂解的caspase依赖激发病原体:大肠杆菌的caspase-11和肺炎链球菌的caspase-8。脓毒症中凝血激活的另一种机制可能是HMGB1介导的。 barbara kleinert obituaryWebSTING N153S knock-in mice These mice carry a N153S (asparagine to serine) substitution in the Tmem173 (transmembrane protein 173 or STING) gene. The mice were created using CRISPR/Cas9 with a single guide RNA designed based on specificity and proximity to the targeted STING mutation site. barbara klemm oberhausen