Ovarian granulosa cell apoptosis
WebOct 26, 2024 · Polycystic ovary syndrome (PCOS) is one of the most incident reproductive endocrine diseases, with a prevalence ranging from 5 to 10% in women of reproductive … WebNov 21, 2024 · Bax-dependent apoptosis is a common pathway of cell death and the balance of Bcl-2 and Bax is a key determinant of the survival or death of GCs. As expected, the level of Bcl-2 and the ratio of Bcl-2/Bax were found to be markedly reduced after down-regulation of GPSM1.
Ovarian granulosa cell apoptosis
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WebJun 1, 2024 · Human ovarian granulosa cell line (KGN cell) was obtained from Prof. Jiangning Zhou as a gift. In previous studies, KGN cell line was considered as a very useful model that mimicked the physiological regulation of steroidogenesis, cell growth, and apoptosis in human granulosa cells [29, 30]. WebApr 1, 2015 · The resistance to apoptosis is mediated by products of several cAMP-induced anti-apoptotic genes, including inhibitor of apoptosis protein, B-cell lymphoma-extra large (BCL-X), and B-cell lymphoma-2 (BCL-2). Enhanced FSH-induced inhibitor of differentiation 2 (ID2) mRNA expression within the GC layer also occurs coincident with selection.
WebJun 1, 2024 · Section snippets Cell lines and cell culture. Human ovarian granulosa cell line (KGN cell) was obtained from Prof. Jiangning Zhou as a gift. In previous studies, … WebJan 1, 2024 · A Foxl2 promoter-driven knockout of Yap1 in ovarian granulosa cells resulted in increased apoptosis of granulosa cells, decreased the number of corpora lutea, reduced ovarian size, and resulted in subfertility of transgenic mice 40. The relationship between miR-484 and YAP1 has been previously reported.
WebMore densely housed mice showed increased serum and local ovarian angiotensin II levels; furthermore, increased angiotensin II levels induced granulosa cell apoptosis in vivo. In rodents, treatment with angiotensin II has been shown to modulate ovarian steroidogenesis in vitro within cultured granulosa and theca cells, causing atresia [ 26 ]. WebDec 23, 2024 · Granulosa cells apoptosis happens by the omission of miR-21 through particular inhibitors; therefore miR-21 acts for granulosa cells maintenance in the follicles prior to the ovulation [ 41 ]. Notably, in vivo miR-21 action blockade through using blocking oligonucleotide into the ovarian bursa stopped ovulation [ 9, 41 ].
WebFeb 27, 2024 · This phenomenon induces significant apoptosis of granulosa cells, which is the cellular basis of ovarian follicular atresia [ 86, 87 ], as it leads to reduced levels of sex hormones secreted by non-resting follicular granulosa cells [ 88 ]. In addition to apoptosis, inhibition of autophagy has been shown to be involved in follicular loss.
WebApr 5, 2024 · The regulation of granulosa cells (GCs) proliferation and apoptosis is the key step in follicular selection which determines the egg production performance of poultry. miR-202-5p has been reported to be involved in regulating the proliferation and apoptosis of mammalian ovarian GCs. However, its role in regulating the proliferation and ... edf smart meter in-home display not workingWebJan 10, 2024 · A considerable number of known molecular factors are involved in the regulation of GC apoptosis, including proapoptotic molecules, such as FAS (Fas cell … edf smartpushconfidence interval analysisWebJul 9, 2009 · The ovarian follicle, consisting of an oocyte surrounded by granulosa and theca cells, represents the basic functional unit of the ovary. Follicular growth can be classified into three phases according to their developmental stage and gonadotropin dependence [1–3] (Fig. 1): (1) follicular growth through primordial, primary, and … edf smart meter not working properlyWebNational Center for Biotechnology Information edf smartschoolWebApr 11, 2024 · This may be because full-term PPE promotes the proliferation of pre-granulosa cells, while mid-late pregnancy exposure inhibits apoptosis of pre-granulosa cells, thus affecting the expression of CYP19 in fetal ovarian pre-granulosa cells. However, the specific mechanism needs to be further explored. confidence interval and relative riskWebNov 21, 2024 · The cell proliferation assay (CCK8) and flow cytometry suggested that the small-interfering RNA-induced silencing of Gpsm1 significantly increased apoptosis and … confidence interval business definition