Klf2 endothelial cell

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August undefined, 2024

WebIn the procession of endothelial growth, KLF2 can act with ERG to activate the expression of Flk1 which is the receptor of vascular endothelial growth factor ... Similarly, miR-25–3p targets and represses the expression of KLF2 and KLF4 in endothelial cells, inhibiting the production of ZO-1, occluding, and Claudin5, ... WebNational Center for Biotechnology Information

KLF2+ stemness maintains human mesenchymal stem cells in …

WebMar 31, 2024 · Gimbrone MA Jr, Garcia-Cardena G. Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis. Circ Res. 2016 Feb 19;118(4):620-36. doi: 10.1161/CIRCRESAHA.115.306301. WebJan 24, 2024 · The role of KLF2 (Kruppel like factor 2) in ECs (endothelial cells) dysfunction and homeostasis. KLF2 is the major MSTF regulated by shear stress: down-regulated by … is chara playing

KLF2 and KLF4 control endothelial identity and vascular integrity

WebJun 23, 2024 · The protein levels of endothelial markers (PECAM1 [platelet endothelial cell] adhesion molecule-1 and VE-Cadherin) were reduced in human umbilical vein ECs (HUVECs) with KLF2 knockdown. The … WebFeb 14, 2013 · Krüppel-like factor 2 (KLF2) is expressed in endothelial cells in the developing heart, particularly in areas of high shear stress, such as the atrioventricular (AV) canal. KLF2 ablation leads to myocardial thinning, high output cardiac failure and death by mouse embryonic day 14.5 (E14.5) in a mixed genetic background. Webactivating protein-1 (AP-1) and NF-κB in human endothelial cells and VSMCs [48], probably mediated by Rho and Rac Attenuation of Inflammatory Damage proteins [49, 50]. Further study shows that statins suppress Inflammatory processes have a key role in the the activation of NF-κB probably through inducing the pathophysiology of ischemic stroke ... ruth ozeki the tale for the time being 2013

Free fatty acids induce coronary microvascular dysfunction via ...

WebMay 25, 2024 · Kruppel-like factor 2 (KLF2) is a laminar flow-inducible transcription factor primarily expressed by endothelial cells that play an important role in the regulation of endothelial function [3,4]. Studies have shown that KLF2 induces eNOS expression and increases NO production in cultured human umbilical vein endothelial cells (HUVECs) and … WebAug 7, 2024 · KLF2 regulates a network of genes that maintain vascular barrier integrity and confer EC quiescence, resulting in an anti-inflammatory, anti-thrombotic EC phenotype ( Dekker et al., 2006 ). Interestingly, high LSS suppresses EC glucose uptake, glycolysis and mitochondrial respiration via a KLF2-dependent mechanism ( Doddaballapur et al., 2015 ). ruth ozeki books in orderWebThe endothelium lines the luminal surface of the arterial wall and is in direct contact with blood flow. The pulsatile shear stress (PS) at straight parts of arteries maintains endothelial homeostasis, whereas oscillatory shear stress (OS) at bifurcations and curvatures impairs endothelial function. ruth ozeki written works

"WebFeb 5, 2024 · KLF2 is a member of the Kruppel-like transcription factor family of proteins containing highly conserved DNA-binding zinc finger domains. KLF2 participates in the differentiation and regulation of the functional activity of monocytes, T lymphocytes, adipocytes, and vascular endothelial cells. " - Klf2 endothelial cell

Klf2 endothelial cell

Roles of KLF4 and AMPK in the inhibition of glycolysis by ... - PNAS

WebMar 4, 2024 · Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. WebMay 12, 2024 · Endothelial cell MEKK3-KLF2/4 signaling can be activated by both fluid shear forces and inflammatory mediators, and it plays roles in cardiovascular development and disease that have been linked to both stimuli.

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WebJan 24, 2024 · Kruppel like factor 2 (KLF2) is a mechanosensitive transcription factor participating in the regulation of vascular endothelial cells metabolism. Activating KLF2 in endothelial cells induces eNOS … WebApr 10, 2024 · Understanding the endothelial cell function in vascular biology has been pivotal for grasping the repair mechanisms in ischaemic tissue and during cardiovascular diseases. ... endothelial miR-92a is regulated by the master EC transcription regulator KLF2, and its expression increased in arterial regions where complex hemodynamic conditions …

WebMay 5, 2004 · Overexpression of KLF2 in umbilical vein endothelial cells robustly induced endothelial nitric oxide synthase expression and total enzymatic activity. In addition, KLF2 … WebIn the human body, KLFs are mainly involved in various physiological processes such as enhancing immune response, maintaining the normal function of vascular endothelium, …

WebTzima et al showed that platelet and endothelial cell adhesion molecule-1 (PECAM-1, also called CD31), vascular ... showed significantly less induction of KLF2 expression than ciliated cells in the embryonic heart. 92 Primary cilia on ECs protrude into the vascular lumen and are molecular switches for Ca 2+ and NO signalling. 93 The ... WebLung Kruppel-like factor/KLF2 is highly expressed in the vascular endothelium (17). Systemic knockout of KLF2 results in embryonic death and abnormal vessel formation (17, 18). However, our understanding of the function and targets of KLF2 in endothelial biology have been lacking to date. We recently identiﬁed KLF2 as a novel transcriptional reg-

WebMar 13, 2024 · The AMPK/KLF2 axis activates the expression of endothelial nitric oxide (NO) synthase (eNOS) in endothelial cells, subsequently promoting the release of vasodilator-NO (21). Endothelial cell-derived NO serves key roles in vasodilation, inhibition of platelet aggregation and reduction of leukocyte adhesion, and as an antioxidant (22).

WebJul 25, 2005 · We hypothesized that Lung-Kruppel–like factor (LKLF/KLF2), a novel and potent regulator of endothelial gene expression, may mediate the downstream effects of statins. Here we report that statin-induced expression of endothelial NO synthase (eNOS) and thrombomodulin is KLF2 dependent. ruth paceWebFeb 23, 2024 · Inducible endothelial-specific deletion of Klf2 and/or Klf4 reveals that a single allele of either gene is sufficient for survival, but absence of both (EC-DKO) results … ruth p mcdougalWebKLF2orchestrates vascular homeostasis and serves as a key molecular switch between proinflammatory atheroprone and quiescent atheroresistant endothelial phenotype. This characteristic is attributed to its ability to activate atheroprotective and inhibit atherogenic endothelial transcription programs. is chara floweyWebJul 28, 2024 · Endothelial cells (ECs) are professional mechanosensing cells that constantly perceive and respond to the hemodynamic forces generated by blood flow. 1 The hemodynamic forces play a critical role in the development and geometric distribution of atherosclerosis, 2 a leading cause of death in patients with stroke and myocardial … ruth pace obituaryWebJul 22, 2010 · KLF2 is a shear stress-induced factor that confers antiinflammatory and antithrombotic properties to the vascular EC. 15–21 However, despite the acknowledged importance of the endothelium in determining vascular barrier function, studies assessing the role of KLF2 (or any other member of this gene family) have not been reported. is character creator 3 worth itWebNov 13, 2024 · Krüppel-like Factor 2 (KLF2) is an important indicator of the stemness of human MSCs (hMSCs) and as early vascularization is also critical for bone regeneration, we used KLF2 as a novel in vitro marker for MSCs and investigated the angiogenesis and osteogenesis between KLF2 + MSCs and endothelial cells (ECs). is charachorder legitWebFeb 3, 2008 · KLF2 repressed the expression of several chemokine receptors, including CCR3 and CCR5. We thus conclude that KLF2 maintains proper T cell migration patterns … is chara playing tonight