Greater than dose proportional
WebBoth the maximal plasma concentration (C max ) and the AUC from 0 h to infinity (AUC 0 -) were dose proportional, as shown in Fig. 4. Safety data. Inhalation of capreomycin was not associated with ... WebNov 13, 2024 · Insulin exposure was more than dose proportional, increasing with dose 1.08 for LIS and dose 1.35 for TI. Time to reach 10% of the maximum glucose infusion rate was 7 to 15 min for TI vs 21 to 38 min for LIS. End of effect was dose dependent for both treatments, ranging from 2 to 6 h (TI) and 5 to 10 h (LIS).
Greater than dose proportional
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Webbetween 150 and 1200 mg were slightly greater than dose proportional. Increases in AUC were dose proportional after 3 weeks of dosing with doses from 300 to 1200 mg twice daily. The pharmacokinetic parameters after administration of amprenavir 1200 mg b.i.d. for 3 weeks to HIV-infected subjects are Webproportionality. That is, for a given dose range they make an overall conclusion about dose proportionality. The ANOVA approach has also allowed assessing proportionality on a …
WebApr 30, 2005 · Ultra–wideband (UWB) technology has increased with the use of various civilian and military applications. In the present study, we hypothesized that low-dose UWB electromagnetic radiation (UWBR) could elicit a mitogenic effect in AML-12 mouse hepatocytes, in vitro. To test this hypothesis, we exposed AML-12 mouse hepatocytes, to … WebApr 13, 2024 · A Cox proportional hazard model showed that patients with a class I mHA count greater than the population median had an increased hazard of GvHD mortality (hazard ratio [HR] ... A multi-mHA analysis in an HLA haplotype shows a dose–response relationship between the number of mHAs present (0–2) and the hazard for various …
WebApr 14, 2024 · The Cox proportional hazard model was applied by stratifying by this dichotomous variable, which indicated whether a person had been followed until 15 December 2024 (value = 0) or after this cut-off date (value = 1). ... the coefficient for COVID infections after the 2nd dose was significantly greater than that for previous COVID … WebDe très nombreux exemples de phrases traduites contenant "increased greater than dose proportionally" – Dictionnaire français-anglais et moteur de recherche de traductions ...
WebApr 13, 2024 · 1) First -order elimination: drug assumed to rapidly equilibrate into volume of distribution; plasma concentrations decline according to first-order kinetics; elimination rate from plasma is proportional to plasma concentration, fraction eliminated per unit time is elimination rate constant (k el ). dCp dt = − kelCp Cp = C0e − kelt
WebNov 13, 2024 · The greater than dose-proportional increase in TI GIR AUC provided no evidence of saturation in total effect over the range of 10–120 U. The geometric mean … bio cranberryWebDextromethorphan when co-administered with bupropion displays nonlinear pharmacokinetics at steady state, with greater than dose-proportional changes in AUC and c max for varying doses of dextromethorphan [60 to 120 mg (0.67-1.33 times the maximum recommended dose of AUVELITY)] and less than dose-proportional … biocredits iiedWebNov 22, 2010 · Greater than dose proportional increases were observed in the area under the concentration-time curve estimated to infinity (AUC 0-∞) and estimated to 4 hours … biocredits to finance nature and peopleWebMar 1, 2024 · The area under the concentration-time curve increased with a greater than dose-dependent manner from 1 to 30 mg and resulted in a dose-dependent increased from 30 to 60 mg. ... SY-007 showed nonlinear pharmacokinetics with a greater than dose-proportional increase across the evaluated doses, which also been observed in … biocrom chileWebEarly clinical data suggested greater than dose proportional increases in exposure following oral administration. The aim of the present studies was to definitively characterize the oral and IV dose proportionality of telcagepant. Methods. Healthy adult subjects were enrolled in two separate open-label randomized dose proportionality studies: dahlberg gibson learning center columbus ohioWeb12,250 IU single doses indicates that increases in anti-Xa activity are greater than dose proportional relative to the increase in dose. Following a single SC injection of tinzaparin ... based on the area under the anti-Xa and anti-IIa time profiles, is 2.8 and is higher than that of unfractionated heparin (approximately administrations) is 86. ... biocrom uffWebApr 13, 2024 · The slope is directly proportional to the elimination half-life; the steeper the slope (i.e., increase in duration with an increase in dose), the longer the elimination half … dahlberg light and power outages