Ctgf antibodies

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August undefined, 2024

WebJun 13, 2024 · Our data indicate that inhibition of CTGF signaling presents an attractive therapeutic approach in SSc. Anti-connective tissue growth factor (CTGF/CCN2) monoclonal antibody attenuates skin fibrosis in mice models of systemic sclerosis ... (KO)) or a human anti-CTGF monoclonal antibody, FG-3019. Methods: Angiotensin II … WebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast activation protein (FAP) and the connective tissue growth factor (CTGF) can function in tumor-associated stromal cells but are practically inactive in normal adult cells. Accordingly, the …

CTGF Antibodies

WebApr 8, 2016 · Purpose To evaluate and model the pharmacokinetic and pharmacodynamic behavior in rats of FG-3019, a human monoclonal antibody targeting connective tissue growth factor (CTGF). Methods FG-3019, human CTGF (rhCTGF), or the N-terminal domain of rhCTGF were administered intravenously to rats and concentrations of these proteins … WebMar 18, 2024 · CTGF Antibody (L-20): sc-14939. 4.7 (15) Write a review Ask a question. CTGF Antibody (L-20) is a goat polyclonal IgG; 100 µg/ml. epitope mapping within an internal region of CTGF of human origin. Discontinued polyclonal antibody. See … dickey chaney

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WebJun 13, 2024 · Anti-connective tissue growth factor (CTGF/CCN2) monoclonal antibody attenuates skin fibrosis in mice models of systemic sclerosis. Our data indicate that … WebOct 26, 2024 · Connective tissue growth factor (CTGF)-induced angiogenesis is a crucial factor in rheumatoid arthritis (RA), but CTGF-interacting protein and related molecular mechanism of their interaction have not been fully elucidated. CTGF-interacting proteins were identified through the LC-MS/MS analysis of the Co-IP products from fibroblast-like … WebAnti-CTGF antibody Specifications. Our Abpromise guarantee covers the use of ab50044 in the following tested applications. The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user. Applications. SDS-PAGE. Functional Studies. Form. Lyophilized ... dickey catering

Human CTGF/CCN2 C-Terminus Antibody AF660: R&D …

WebThis affinity purified antibody,in conjunction with Biotinylated antibody Human CTGF (AP01150BT) as a detectionantibody, allows the detection of at least 0.2-0.4 ng/well of recombinant Human CTGF. Western blot: To detect Human CTGF this antibody can be used at a concentration of0.1-0.2 μg/mL. WebCTGF/CCN2 was detected in immersion fixed paraffin-embedded sections of human kidney array using Goat Anti-Human CTGF/CCN2 C-Terminus Antigen Affinity-purified Polyclonal Antibody (Catalog # AF660) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and ... citizens bank refinance mortgage ratesWebCTGF/CCN2 was detected in immersion fixed paraffin-embedded sections of human kidney array using Goat Anti-Human CTGF/CCN2 C-Terminus … dickey center for international understanding

"WebCTGF, also known as CCN2, is a member of the CCN family of matricellular proteins. CTGF, a cysteine-rich, matrix-associated, heparin-binding protein, is widely expressed in various human tissues and organs. CTGF has important roles in many biological processes, including cell adhesion, migration, proliferation, angiogenesis, skeletal ... " - Ctgf antibodies

Ctgf antibodies

CTGF Polyclonal Antibody (500-P252-1MG) - thermofisher.cn

WebMouse anti Human CTGF antibody recognizes the connective tissue growth factor, also known as CCN2, IGF-binding protein 8, and IGFBP-8. CTGF is a matricellular protein … WebThis antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human CTGF (500-P252Bt) as a detection antibody, allows the detection of at least 0.2 …

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WebAnti-CTGF antibodies significantly reduced skin fibrosis and collagen contents compared with the control group. These results suggest that our anti-CTGF antibodies are capable of blocking the development of skin fibrosis at least partially and these anti-CTGF neutralizing antibodies may be useful as the feasible strategy to treat skin fibrotic ... WebMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val174 of …

WebTarget Information. Connective Tissue Growth Factor (CTGF), also called CCN2, is a member of the CCN family. CTGF is a secreted protein produced by umbilical veins and vascular endothelial cells. CTGF possesses an Insulin-like Growth Factor (IGF)-binding domain, a thrombospondin type 1 domain, and a cysteine knot region. WebAug 1, 2024 · Background: Radiotherapy is a mainstay for the treatment of lung cancer that can induce pneumonitis or pulmonary fibrosis. The matricellular protein connective tissue growth factor (CTGF) is a central mediator of tissue remodeling. Methods: A radiation-induced mouse model of pulmonary fibrosis was used to determine if transient …

WebRecombinant Mouse CTGF Protein expressed from Escherichia coli (E. coli). Conjugated to His tag.Order Protein ABIN7122479 online. ... Comparison List Basket Phone: +1 877 … WebMouse Monoclonal Anti-CTGF Antibody against Human connective tissue growth factor. Antibody validation: Validated for Immunohistochemistry and Western Blot Support

WebCTGF is a heparin-binding pleiotropic growth factor involved in chondrogenesis and potentially skeletogenesis. CTGF promotes the adhesion of epithelial cells and fibroblasts, stimulates integrin …

WebAnti-CTGF antibody (ab125943) at 1 µg/ml + Connective Tissue Growth Factor (CTGF) Recombinant Protein at 0.1 µg Secondary Goat Anti-Rabbit IgG H&L (HRP) at 1/10000 … dickey chest protectorWebAntibodies that detect CTGF can be used in several scientific applications, including Western Blot, Immunohistochemistry, Immunocytochemistry, ELISA and … citizens bank refinance loanWebCtgf Antibody, Anti-CTGF antibody produced in rabbit. Tested Applications: immunohistochemistry 1:20- 1:50, immunofluorescence 1-4μg/mL, immunoblotting None. Sigma-Aldrich Hpa031074. Synonym: Anti-CCN2, Anti-IGFBP8, Anti-connective tissue growth factor, Ctgf Antibody. citizens bank refinance ratesWebJun 1, 2024 · Antibody. As CTGF is a secreted protein, monoclonal antibodies are an option as blockade agents. The most advanced trials are of treatment with FG-3019/pamrevlumab, a humanized anti-CTGF antibody, which has been tested in the clinic for muscular dystrophy, pancreatic cancer, liver fibrosis, idiopathic pulmonary fibrosis, … dickey center dartmouthWebJun 6, 2012 · CTGF is a secreted matricellular protein with very complex biology. It has been shown to modulate many signaling pathways leading to cell adhesion and migration, angiogenesis, myofibroblast activation, and extracellular matrix deposition and remodeling, which together lead to tissue remodeling and fibrosis. It has been reported in the … citizens bank refinance rates homeWebMonoclonal Antibody against Human CTGF Alternative Gene Names CCN2, IGFBP8 Open Datasheet. Price. $505.00. Product Number. AMAb91366. Unit Size. Concentration. Lot dependent. Availability >10 in Stock. Ships. Ready to Ship. Share by E-mail Add to Cart Show all images ... dickey centerWebConnective tissue growth factor (CTGF) is a novel cysteine-rich, secreted protein. Recently, we found that inhibition of the endogenous expression of CTGF by its antisense oligonucleotide and antisense RNA suppresses the proliferation and migration of vascular endothelial cells. In the present study … dickey chapelle books