Cisplatin uptake rates

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August undefined, 2024

WebDec 18, 1998 · Cisplatin transport characteristics demonstrated a saturable component of cisplatin uptake and differences in apparent K M and V max values among the three … WebWhen infused from the basolateral compartment, cisplatin (25 µM, 72 hours) induced toxicity, which was evident as reduced cell number and reduced barrier integrity compared with vehicle-treated chip cultures. Coexposure with the OCT2 inhibitor cimetidine (1 mM) abolished cisplatin toxicity.

Frontiers Cisplatin-Membrane Interactions and Their …

WebFeb 14, 2024 · Cisplatin (60 mg/m2× 2 days per cycle) was administered concurrently with pantoprazole (intravenous [IV], 1.6 mg/kg over 4 hours) on cycles 1 and 2 or cycles 3 and 4 in 12 patients with osteosarcoma (OS) with a median (range) age of 12.8 (5.6–19) years. Audiograms, urinary AKI biomarkers, and serum cystatin C were monitored during each … WebNov 30, 2024 · The increased uptake detected in the M2 population might explain the cisplatin hypersensitivity of this cell type described in the literature. (63−65) However, … read the word

Exploiting the acquired vulnerability of cisplatin-resistant tumors ...

WebNational Center for Biotechnology Information WebMaterials and methods: Cisplatin (60 mg/m 2 × 2 days per cycle) was administered concurrently with pantoprazole (intravenous [IV], 1.6 mg/kg over 4 hours) on cycles 1 and 2 or cycles 3 and 4 in 12 patients with osteosarcoma (OS) … WebThe uptake of cisplatin in renal tubular cells is high, leading to cisplatin accumulation and tubular cell injury and death, culminating in acute renal … The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity Am J Physiol Renal Physiol. read the word of god daily

Cisplatin uptake and release in pH sensitive zeolitic …

The Strange Case: The Unsymmetric Cisplatin-Based Pt(IV) …

WebTwo major issues which hamper the use of the anticancer drug cisplatin are the development of cancer cell resistance and its nephrotoxicity. One possible mechanism … WebJun 30, 2024 · Cisplatin uptake was explored by performing a time course experiment in order to analyze how the distribution of cisplatin uptake changed over time within the … read the word in parenthesesWebJun 23, 2024 · In situations where cisplatin uptake is hindered by encapsulation, it may be beneficial to use ZIFs with larger kno pores that can display a similar rate of retention … read the wolf of wall street online

"WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate … " - Cisplatin uptake rates

Cisplatin uptake rates

Cisplatin-Membrane Interactions and Their Influence on Platinum ...

WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe side effects, including nephrotoxicity and acute kidney injury (AKI) which develop due to renal accumulation and biotransformation of CDDP. WebMar 26, 2024 · Collectively, these lines of evidence documented that the three cisplatin-resistant cancer cells showed increased intracellular hypoxia. To unveil the underlying mechanism of the increased intracellular hypoxia, we tested the glucose uptake rate of both BEL7404 and BEL7404DDP cancer cells.

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WebOct 7, 2002 · We have also found that cisplatin reduced uptake of 64 Cu into wild-type cells; when treated for 2 h with 1 mM cisplatin, the level of 64 Cu uptake was 16% of that of … WebNov 7, 2024 · One of the main limitations to the Pt-therapy in cancer is the development of associated drug resistance that can be associated with a significant reduction of the …

WebCisplatin (cDDP) is an anti-cancer drug used to treat a number of malignancies including breast, testicular, ovarian, prostrate, lung, head, neck, and colon cancers. Recent studies have... WebJan 17, 2024 · NMIBC is of low grade, accounts for approximately 70% of UBC occurrences, and demonstrates a 5-year survival rate of 90%. Even though they are not possibly life-threatening, they have a proclivity for recurrence, ... CTR1 knockdown has been shown to lower cisplatin uptake by over 80% in both yeast and mouse embryonic fibroblasts .

WebApr 14, 2024 · The investigations demonstrated different impacts of cisplatin on CTR1 expression on the single-cell level according to the resistance status. The study showed this interrelation for the first time at the single-cell level. It could be shown in this study that the resistant ovarian cancer cells as compared to the sensitive cells are ... WebSep 18, 2024 · NCBI Bookshelf

WebApr 17, 2024 · Reported rates of cisplatin ototoxicity vary widely, though it is believed that at least half of all patients treated with cisplatin will suffer hearing loss. As cisplatin is widely used, this rate of ototoxicity translates to hundreds of thousands of patients affected each year in the United States alone. chemo, cancer, hearing loss

WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes … how to store bugs in dinkumWebBoth solvated and non-solvated simulations show that cisplatin release rates can be controlled by either ... energies and small pore window diameters will hinder cisplatin … how to store brownies after bakingWebJan 11, 2024 · Studies in cells also showed that cisplatin can be taken up by passive diffusion mechanisms since its accumulation by concentration gradient up to its saturation point was not the rate limiting factor ( … how to store buffy coatWebglomerular ﬁltration rate, higher serum creatinine, and reduced serum magnesium and potassium levels.4,19,20 On the other hand, the long-term effects of cisplatin on renal ... the cisplatin uptake is due to passive diffusion through the plasma membrane, and the remaining half is mediated by an unknown transporter.22 In 2002, ... how to store buccal midazolamWebOct 5, 2014 · The addition of cisplatin to cyclophosphamide and doxorubicin (CAP) has been recently associated with overall response rates of 57% to 100% and complete … read the words in your snare mangaWebDec 15, 2024 · Findings showed the optimum swelling rate was 4903.876%. Then, the loading and release of cisplatin, selected as the hydrogel structure model drug, were … read the word not the colorWebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … read the words by ashley jade online free